Germany central defender Mats Hummels was in the starting lineup for the Group G match against Ghana, which started with Germany-based striker Kevin-Prince Boateng and kept midfield star Michael Essien on the bench after he fought to return to fitness from a toe injury.
Boateng's half-brother Jerome was in the Germany lineup, making it the second time they play against each other at a World Cup.
Coach James Appiah also switched goalkeepers to start with Fatau Dauda, while defender Daniel Opare is out injured.
Hummels was doubtful because of a thigh injury but coach Joachim Loew stuck with the 11 that beat Portugal 4-0.
Germany starting XI: Neuer; Boateng, Mertesacker, Hummels, Hoewedes, Lahm, Khedira, Kroos, Ozil, Muller, Goetze.
Ghana starting XI: Dauda; Afful, Mensah, Boye, Mohammed, Asamoah, Atsu, Muntari, Ayew, Boateng, Gyan.