Ghana coach Goran Stevanovic will hand debuts to youngsters Albert Adomah and Rabiu Mohammed in the friendly against Brazil on Monday.
Another youngster Jordan Ayew will also be handed the chance to play in the friendly to be played in London.
The three players were part of the squad invited for the Africa Cup of Nations qualifier against Swaziland but were not played in the game.
The Serb expressed dissatisfaction after the Friday's nondescript 2-0 win over Swaziland in the Nations Cup qualifier and wants to rejig his personnel.
"I will give Adomah a chance against Brazil. That will be a friendly game and apart from the motivation that comes with playing against Brazil, the players will be more relaxed and that is very good for me," Stevanovic said.
He added that: "I will also give Rabiu Mohammed as well a big part to play. I plan to give players like Jordan Ayew who did not get a chance to play an opportunity to prove themselves and gain some experience on Monday."
Watch the Black Stars 2-0 win over Swaziland