Leaders Berekum Chelsea can afford to lose on Sunday in the final match to halve the Ghana Premier League and still end the year on top.
Chelsea, with a five-point lead, face Mighty Jets who have picked up four points from the last six at the Ohene Djan Stadium.
New Edubiase United, now in second place after accumulating three points from the board room, travel to Kpando to face Heart of Lions.
AshantiGold can deepen the woes of bottom-club BA Stars at the Len Clay Sports Stadium in Obuasi.
Asante Kotoko must end their dire run of form against Wa All Stars at the Baba Yara Stadium.
Real Tamale United host struggling Hearts of Oak at the Tamale Stadium.
Champions Aduana Stars travel to the Golden City Park as guests of Berekum Arsenals.
Ebusua Dwarfs, unbeaten in five matches, are at the Carl Reindorf Park to face Liberty Professionals.
Former leaders Kessben FC have not won a match since October and must halt that at home against a plucky King Faisal side.