The Black Princesses failed to seal an early FIFA U20 Women’s World Cup quarterfinal berth after losing 3-0 to former champions Korea DPR in Toronto on Friday.
Bashir Hayford’s ladies must now avoid defeat in their final Group A match against Finland on Tuesday to progress.
North Korea’s No10 Ri Un-Sim, named player of the match, scored twice to cap a fine performance.
Opening-day victories had left both teams knowing that another win would all but secure their place in the knockout phase and, from the offset, Korea DPR always looked more likely to secure it. Indeed, it took them just six minutes to take the lead, and the goal was all down the improvisation of Ri.
Right-back Song Kyong-Hui had done well with a positive overlapping run and cross, but the ball arrived at an awkward height for the team's talisman.
Undeterred, Ri simply adjusted her body, stooping low on the six-yard line to direct a a delicate header in off the far post.
An unusual early substitution followed, with the referee picking up a knee injury and making way for her fourth official, but the pattern of the game remained unaltered.
Ghana could have found themselves further behind, in fact, had it not been for keeper Victoria Agyei saving well with her legs on two occasions, first from Ri Hyang-Sim and then from Song.
Ri remained the North Koreans' most likely source of a goal though, and with 66 minutes played she came within millimetres of doubling hers and her team's tally.
Rising to meet another cross from the right, she again sent a header towards goal only to see the ball rebound off he underside of the crossbar and be scrambled to safety.
The Korea DPR star would not be denied, though, and with 12 minutes remaining she got her second goal, glancing into the empty net after nipping in ahead of Agyei to meet an outswinging free-kick from Jon So-Yon.
And there was still time for the North Koreans to add a little sparkle to the scoreline.
The opportunity to do so arrived in stoppage time when Agyei missed the ball with a wild attempted clearance and caught Ri Kyong-Hang on the neck.
A penalty was the inevitable consequence, and though Agyei guessed right, Jo Son-Yon's spot kick was accurate and powerful enough to leave her with no chance of keeping it out.