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Black Stars regulars Kwadwo Asamoah and Harrison Afful were on target for their various clubs over the weekend while David Accam also scored from the spot in Helsingborg's friendly loss to Spartak Moscow.
Michael Essien dropped to the AC Milan bench while Shadrach Eghan's FC Twente punched Christian Atsu and Vitesse Arnhem while Richard Kingson kept a clean sheet for Balikesirspor in the Turkish second-tier.
Emmanuel Agyemang-Badu set up a goal for Dusan Basta in Udinese's 3-3 draw at Genoa.
Read more on how Ghanaian players fared across the various leagues for their clubs with Akyereko Frimpong Manson presenting a comprehensive wrap.
Anthony Annan was on the Schalke 04 bench when they beat Bayer Leverkusen 2-1 at the BayArena. Kevin-Prince Boateng played the full 90 minutes for Schalke.
Karim Bellarabi played the full 90 minutes of the game for Eintracht Braunschweig when they beat Hamburg SV 4-2 to boost their survival hopes.
In the Bundesliga II, Arminia Bielefeld remain in the grips of relegation after losing 4-0 at Paderborn. Ghanaian defender Marcel Appiah played the entire 90 minutes of the game for Bielefeld.
Baba Abdul Rahman was in action for Greuther Furth and got booked in the 34th minute as they drew 1-1 with Karlsruher SC.
Evans Owusu Nyarko played the full 90 minutes for Borussia Dortmund II when they beat Chemnitzer FC 3-0.
Attacker Phil Ofosu-Aryeh played the entire 90 minutes for MSV Duisburg when they managed to run away with a 3-2 win over Rot-Weiß Erfurt.
FC Sion lost 1-0 at FC Basel. Ebenezer Assifuah started the game for Sion while Ishmael Yartey came off the bench after 77 minutes.
Samuel Afum was brought on in the last 6 minutes of the game by Young Boys who thrashed Lausanne Sport 5-3 on Sunday.
Youngster Koby Arthur continued to stay out of the Birmingham City team as he failed to make their squad for their 2-1 home loss to Huddersfield. Dutch-born Akwasi Asante was also not in the Birmingham team.
Winger Albert Adomah played full throttle for ten-man Middlesbrough who lost 1-0 at Watford.
Hibernian managed a slender 2-1 win over Ross County. Arsenal loanee Daniel Boateng came off the bench in the 84th minute to play his first game for Hibs while Dutch-born Kevin Luckassen was introduced by Ross County on the 74th minute mark.
Vitória Guimarães sneak past Rio Ave with a 1-0 win. Ghana full-back David Addy played the entire 90 minutes of the game for Vitória Guimarães.
Haminu Dramani was not in the Gil Vicente team when they lost 2-1 to FC Porto at their own backyard.
In the Liga de Honra, Alhassan Wakaso played the entire 90 minutes for Portimonense who held Penafiel to a 0-0 draw.
Ghana's Lee Addy played the entire 90 minutes for Dinamo Zagreb who beat Split 2-1 at their favourite Stadion Maksimir.
Lokeren remain in the championship play-off place after managing a 1-1 draw at Gent. Ghanaian youngster Eugene Nana Ansah warmed the bench for Lokeren but Nana Akwasi Asare played the entire minutes for Gent.
Frank Acheampong missed Anderlecht's 2-0 win over Mons with injury.
Genk recorded their second win in five games after beating Lierse SK 1-0. And, Ghana midfielder Bennard Kumordzi played in midfield for the Blues. Marvin Ofori-Appiah was not picked by Genk for the game.
Abdul Yakinu-Iddi was injured while French-born Jerry Vandam missed KV Mechelen's 1-1 home draw with KV Oostende.
Injury kept Daniel Opare out of the Standard Liege team when they posted a 2-1 win over Sporting Charleroi. Former Heart of Lions midfielder Abraham Kudemor was not in the Sporting team.
Former Ghana U17 midfielder Enock Adu-Kofi was not picked by Club Brugge for their 3-1 home win over Kortrijk.
In the Second Division, midfielder Stephen Asamoah played for AS Eupen when they lost 1-0 at home to Mouscron-Péruwelz.
Richard Kingson manned the post for Bal?kesirspor when helped them to beat Gaziantep BB 1-0 to keep their title ambitions in sight.
Striker Kwame Karikari missed the game through injury.
Emmanuel Banahene was not in the ?anl?urfaspor when they lost 1-0 to Fethiyespor.
FC Twente moved to second place after beating dethroned leaders Vitesse Arnhem 2-0 at the De Grolsch Veste. Winger Shadrach Eghan played 69 minutes for Twente while Christian Atsu was taken off after 79 minutes by Vitesse.
PSV Eindhoven won their third game on a row after beating Heracles Almelo 2-1. Half-Ghanaian Memphis Depay scored the first goal for PSV.
Kwame Quansah returned to the Heracles team but warmed the bench in the entire 90 minutes of the game. Matthew Amoah and Edwin Gyasi both did not travel with the team.
Cambuur continued their revival under Elvis Manu as they beat PEC Zwolle 3-1 and bombed themselves out of the relegation zone. Manu who is on loan from Feyenoord played the full 90 minutes but Fred Benson was not in the Zwolle team.
Defender Mitch Apau came off the bench in the 67th minute to play for RKC Waalwijk who lost 3-1 at home to NEC.
Jeffrey Sarpong played 86 minutes for NAC Breda who drew 1-1 with Feyenoord Rotterdam.
Center-back Johan Kappelhof was at the heart of defence for Groningen when they beat Go Ahead Eagles 1-0. Kodjo Amevor warmed the bench Go Ahead Eagles bench.
In the Eerste Divisie, leaders Dordrecht were held to a 1-1 draw by Jong Ajax. Attacker Erixon Danso was a full-timer for Dordrecht while Kevin Tete also played the full 90 minutes for Jong Ajax.
Fortuna Sittard and Achilles '29 played out a 0-0 stalemate on Friday. Swedish-born Ghanaian striker Patrick Amoah climbed off the bench in the 68th minute to play for Sittard.
Striker Jonathan Opoku did not travel with the Oss team when they lost 3-1 against Helmond Sport.
VVV Venlo posted a comfortable 3-0 win over Jong Twente. Ghanaian midfielder Yahaya Mustapha was booked in the 74th minute and he played the full 90 minutes of the game for Twente.
Andre Ayew played a key role for Olympique Marseille when they held Saint-Etienne to a 1-1 draw.
Jonathan Mensah was not in the Evian TG team that threw away a 2-0 lead to draw with Lille on Sunday.
Sochaux recorded their second win in three games after beating Guingamp 1-0. Ghana attacker Jordan Ayew played 62 minutes for Sochaux.
Ghana defender John Boye watched from the stands as his Stade Rennes side drew 2-2 with Montpellier.
Abdul Majeed Waris played 80 minutes for Valenciennes who got punished 3-0 by Paris Saint-Germain.
In the Ligue 2, AS Monaco loanee Dennis Appiah played the full 90 minutes for Caen who beat Arles Avignon 1-0.
Kwame Nsor watched his Metz side from the screen when they managed a 0-0 away draw with Nîmes.
Richmond Boakye-Yiadom came off the bench to play the last six minutes of the game for Elche FC who drew 0-0 with Osasuna.
In Granada's 1-0 win over Real Betis, youngster Fatau Mohammed played the entire duration of the game while Richard Boateng warmed the bench for them.
Hércules managed to beat Real Mallorca 1-0 at their own backyard. Atletico Madrid loanee Thomas Partey came off the bench to play the last 16 minutes of the game for Mallorca.
Goalkeeper Razak Brimah kept a clean sheet for Córdoba II when they beat Sevilla II 1-0 on Sunday afternoon.
Neither Isaac Appiah nor Isaac Asare was in the Atletico Madrid II team when Atletic Club II beat them 1-0.
Michael Anaba and Paul Quaye were both in action for Elche II and Espanyol II respectively when they played out a 2-2 draw on Sunday afternoon in the Segunda B.
AC Milan needed a Mario Balotelli strike to beat Bologna 1-0 at the Stadio San Siro. Sulley Muntari came off the bench to 27 minutes for Milan but Michael Essien sat on the Milan bench.
AC Milan loanee Kingsley Boateng watched from the bench as his Catania side beat Lazio 3-1 on Sunday.
Kwadwo Asamoah scored a sensational 17th minute opening goal for Juventus when they beat Chievo Verona 3-1 at the Juventus Arena on Sunday.
Alfred Duncan played 76 minutes for nine-man Livorno who beat Cagliari 2-1 in an awa fixture.
Emmanuel Agyemang-Badu set up the opening goal for Dusan Basta with a miraculous cross as Udinese drew 3-3 at Genoa. Badu played the full 90 minutes of the game but compatriot Isaac Cofie was unused by Genoa.
Afriyie Acquah was replaced in the 68th minute by Parma who disgraced Atalanta 4-0 at their favourite Stadio Atleti Azzurri d'Italia in Bergamo.
Sassuolo continue to languish at the foot of the table after suffering a 2-0 home loss to Napoli. Midfielder Raman Chibsah came off the bench in the 67th minute to play for Sassuolo.
In the Serie B, Masahudu Alhassan played the entire 90 minutes for Latina who pipped Cittadella 1-0.
Maxwell Acosty played 67 minutes for Carpi who held Empoli to a 1-1 draw.
Nii Nortey Ashong was a bench warmer for Spezia in their 3-1 home triumph over Crotone.
Moro Al-Hassan was unused by Cesena in their 0-0 draw with nine-man Palermo.
Ahmed Barusso was not in the Novara team when they lost 1-0 to Padova.
Brescia and Ternana drew 1-1, Mase Nana Addo Welbeck and former Inter Milan Primavera striker Isaac Ntow were not in the Brescia team.
Amidu Salifu was a full-timer for Modena and helped them to beat Bari 4-0 to boost their promotion chances.
Croaked Daniel Agyei and Abdul Basit watched from the stands when their Free State Stars beat Golden Arrows 2-1 in the Absa Premier League on Saturday.
Fatau Dauda completed his first 90 minutes of action for Orlando Pirates but they lost 1-0 to Polokwane City.
Rashid Sumaila was on the Sundowns bench when they posted a 3-2 win over Ajax Cape Town.
Mpumalanga Black Aces beat Maritzburg United 2-1. Defender Awal Mohammed played the full 90 minutes for United but Frank Sarfo-Gyamfi sat on the bench.
Ghana defender Harrison Afful scored an 18th minute goal for Esperance de Tunis when they posted a 2-0 win over Stade Tunisien.