Espanyol are looking to replace midfielder Mubarak Wakaso during the January transfer window.
The 22-year-old will be on international duty with the Black Stars at the 2013 Africa Cup of Nations to be held in South Africa.
The Spanish side had their request to have the player delay his arrival for Ghanaâ€™s pre-Nations Cup camp rejected by the Ghana Football Association earlier this week.
Espanyol will therefore miss the services of the player in their biggest match of the season against Barcelona on January 6.
Thanks to his speed and capacity overflow, Espanyol boss Javier Aguirre has used the Ghanaian in his starting lineup in the company of centre forward Sergio Garcia.
The game will be crucial for the blue and white as they are stucked in the relegation zone.
This is the first Catalan derby for Javier Aguirre, who along with his compatriot, defender Hector Moreno, seek to give the first surprise of 2013.