Ghana could seal their place in the 2015 AFCON if they win against Uganda on Saturday.
The Black Stars are already on top of Group E with 8 points and could further stretch it to 11 points and qualify for the tournament which will come off in Equatorial Guinea after Morocco pulled out as host.
However, the Black Stars are facing a difficult game with captain and record scorer Asamoah Gyan and Juventus midfielder Kwadwo Asamoah missing with injury.
Lorient's Jordan Ayew will also sit out with suspension.
Uganda are third on the table and are keen to breathe a live into their campaign and brighten their qualification chances.
The Cranes frustrated Ghana to a 1-1 draw in Kumasi but have failed to keep and must now beat Ghana to survive.
Ghana's last visit to Uganda came in July 2004 in a World Cup qualifier when Ghana held them to a 1-1 draw in Kampala.
If Uganda lose this game, they could be out of the race for qualification.