Hosts Ghana will play Gambia in the tournament opener of the 2017 West African Football Union (WAFU) tournament on 9 September in Sekondi.
But the Black Stars B must win that opener to possibly meet sworn rivals Nigeria who also face Sierra Leone.
The other Group A matches Mali face Mauritania and Guinea play Guinea Bissau.
Group B will be based in Cape Coast with the opening knockout fixtures involving African highest ranked nation Senegal versus Liberia.
Ivory Coast have been paired with Togo; Benin will clash with Cape Verde and Burkina will play Niger.
The winners will remain in the Group for the round-robin exercise which will see the two best teams advance to the semi-final.
The final of the inaugural 16-team tournament will be played on 24 Septmeber.