Ghanaian duo Afriyie Acquah and Alfred Duncan will be playing under a new coach at Sampdoria next season following the resignation of Sinisa Mihajlovic.
The 46-year-old is stepping out having led the club to seventh in Serie-A.
Both Afriyie Acquah and Alfred Duncan could extend their stay at Sampdoria following the expiration of their loan agreements with the club.
They will however be playing under a new coach at Samp once they decide to remain with the side.
Mihajlovic who is heavily inspired by former US President John F. Kennedy bid an extensive farewell to the club on Monday.
"We must use time as a tool, not as a crutch,†the Serb said.
"Not to ask what Samp could do for them, but what they could do for Samp."
Mihajlovic added that he was "proud" to have left behind a squad full of "commitment, professionalism and hard work", and had repaid "a moral debt" to a club who had helped him in a "difficult moment of my career as a young footballer" when they signed him in 1994.
The Serb joined Sampdoria in 2013 and guided the side to 12th in his first season before leading them to seventh this season – a finish which could see the side play in Europe next season.