New Kotoko coach Bogdan Korak failed to halt the club's slide in the league as they crashed to their fourth straight defeat in a 2-1 home defeat to New Edubiase.
Midfielder Daniel Nii Adjei converted a penalty for Kotoko but two first half goals by Edubiase striker Nuhu Fuseini decided the game in favour of the visitors.
Berekum Arsenals handed Kessben FC their second straight defeat at the Golden City Park with a 2-0 win.
Goals from Francis Aggrey in the 17th minute and another strike from Nana Poku sealed the fate of the ex-league leaders.
All Stars moved to second place following a 3-1 win over BA Stars.
Nathaniel Asamoah grabbed a doubled before substitute Fatau Owen added the third to consign struggling BA Stars to the defeat.
At the death of the game substitute Oscar Amponsah got a consolation for the visitors.
Mighty Jets enhanced their chances of beating the drop by beating favourites Hearts 1-0, their second win in a row, at the Accra Sports Stadium.
Ghana Under-20 midfielder Aaron Amoah scored the match winner.
Liberty Professionals shared the spoils with champions Aduana Stars at the Karl Reindorf Park.
Ebusua Dwarfs posted a 3-1 win over leaders Berekum Arsenals at the Robert Mensah Stadium.
Seidu Banson fired the opener after a quarter of an hour, Michael Nsaidoo added the second in the 25th minute before captain Bismark Asiedu added the third on 70 minutes.
Chelsea midfielder Abdul Basit got the consolation in the 75th minute.
The match between Heart of Lions and Real Tamale United was rained off.
AshantiGold play King Faisla in the late kick-off.