Kwesi Appiah insists the unpredictable nature of Cape Verde makes them a dangerous side ahead of their meeting on Saturday.
The two go-head-to-head in the first quarter-final clash in the tournament at the Nelson Mandela Bay stadium in Port Elizabeth.
The Nations cup debutant secured their qualification after placing second in group A.
Kwesi Appiah revealed in his post-match conference after the 3-0 win over Niger that he would have preferred to play Nations Cup favourites Cote Dâ€™voire in the quarter-finals than the tiny Islanders.
He insisted at Friday's pre-match conference that their less-fancied opponent remains his biggest threat.
â€œI know every single player in Ivory Coast. If Iâ€™m playing Ivory Coast, there will automatically pressure on them likewise us,â€ Appiah said
â€œBut with Cape Verde, they have never even qualified to the quarter-final before and so for them to be there is a big achievement for them.
â€œSuch teams when youâ€™re playing them, they come all out without any pressure on them compared to us.
The last time that Ghana played the Islanders was in November 2012 in a warm-up match where Ghana won 1-0 thanks to a goal from Wakaso Mubarak.