Leaders Berekum Chelsea can maintain their position with victory at Liberty Professionals on Wednesday.
The Blues were comprehensive 2-0 winners against defending champions Asante Kotoko and are now on cloud nine.
Liberty tasted a late defeat against Wa All Stars on the road last Sunday and must avert a fourth straight defeat.
The Scientific Soccer Lads have been without a win since beating Tema Youth at home late November.
George Lamptey's side have lacked the firepower this season and are less-fancied to halt the 2011 league champions.
Berekum Chelsea could feature their four players who just returned from DR Congo where there are reports they have signed pre-contracts with Don Bosco and TP Mazembe.