Medeama host Berekum Chelsea in the top liner of this weekend's MTN Ghana FA Cup round of 16 matches.
The league leaders are at home against the 2011 Ghana Premier League champions who are snapping at the heels of the Tarkwa-based side on the league table.
In the first round of the Ghana Premier League, Medeama won 1-0 at the Tarkwa T&A Park and Chelsea will be fighting for revenge.
t is also an opportunity for Chelsea to settle scores with Medeama who beat them 1-0 at the Tarkwa T& A in the first round.
Hearts of Oak have a relatively easier task at home when they play Starke FC.
Aduana Stars visit Tema Youth at the Tema Stadium.
On Saturday, Bibiani Gold Stars host Premier League giants AshantiGold.
Second-tier side Sekondi Eleven Wise will entertain Nania FC at the Sekondi Park on Monday.
Amidaus Professionals will be seeking to replicate their impressive league form when they host Guan United on Tuesday.
On Wednesday, Heart of Lions will host Mighty Jets at the Kpando Park and Asante Kotoko play Rainbow FC.