Medeama will play as guest of Mamelodi Sundowns in the first leg tie of the CAF Confederation Cup play-off on Saturday May 7, GHANAsoccernet.com can confirm.
The Ghanaian side will travel to South Africa for the crucial tie in Pretoria on Wednesday May 4.
Medeama will be engaged in their final Premier League game at Wa All Stars on Sunday before they fly out of the country.
Medeama recorded a dramatic 1-0 win over Inter Allies in an outstanding Premier League game on Wednesday.
Medeama reached this stage after beating Sudanese side Al Shendi 2-0 on aggregate.
The two-time FA Cup champions remain Ghana's surviving team in Africa inter-club competition this year.