Medeama will be without influential trio Malik Akowuah, Moses Sarpong and Daniel Amoah for this weekend's crucial Premier League game at Dreams FC.
Midfield dynamo, Akowuah suffered a minor knock in the Mauves historic CAF confederation cup victory against Mamelodi Sundowns in midweek.
Whilst Daniel Amoah and Moses are part of the National U-20 team, Black Satellites, that has travelled to Ethiopia for the African Youth qualifier.
Coach Didi Dramani has included the duo in his 18-man squad for the second qualifying round first leg assignment in the Ethiopian capital Addis Ababas, scheduled for Sunday
This means the three players will not be available for the clash against the Dawu-based club at the Theatre of Dreams.