Striker Alvaro Morata will make his first start for Chelsea since arriving from Real Madrid as they take on Tottenham Hotspur at Wembley.
Tiemoue Bakayoko, a summer signing from Monaco, makes his debut for the club in what is Tottenham's first league game at Wembley.
Blues centre-back Gary Cahill, suspended after his sending off in the opening day home defeat to Burnley, is replaced by Andreas Christensen.
Speaking on Friday, Chelsea boss Antonio Conte said: "Morata is ready to start the game. He needs to improve his physical condition and he needs a bit of time to reach the top, but he's in contention for the game."
Tottenham bring in Kieran Trippier for Kyle Walker-Peters at right-back, while in midfield Victor Wanyama comes in for Moussa Sissoko.
Tottenham Hotspur: Lloris, Dier, Alderweireld, Vertonghen, Trippier, Wanyama, Dembele, Davies, Alli, Eriksen, Kane.
Chelsea: Courtois, Christensen, Luiz, Rudiger, Azpilicueta, Kante, Bakayoko, Alonso, Moses, Willian, Morata.
Source: espn.co.uk