Aduana Stars were beaten 1-0 by Libyan side Al Tahaddy in the CAF Champions League preliminary qualifying round first leg tie last Sunday in Egypt.
Mahmoud Ali connected home with a follow up after a powerful shot came off the cross bar.
Aduana Stars tried to come back into the match but could not advantage of the few scoring opportunities created.
Winger Zakaria Mumuni had his curled effort from inside the box flapped away by the Al Tahaddy goalkeeper.
The return leg will be played in Dormaa Ahenkor next Wednesday.
Watch highlights of Aduana Stars defeat to Al Tahaddy: