AshantiGold SC suffered a shocking 1-0 defeat at home to Bechem United at the Len Clay stadium on Wednesday.
The loss leaves the Miners stack at the 5th position on the league standings.
Bechem United move two places up on the league table with the vital win.
Thomas Duah made two changes to his squad that drew with Aduana Stars 0-0 last weekend.
Kwadwo Amoako who has recently earned a call up to the Black Stars returned from suspension to replace Atta Kusi.
Stephen Owusu Bahanene also came in for Mubarik Yussif who was suspended from the match.
Bechem United coach Kwaku Danso made several changes to his team with Emmanuel Asante making a comeback from suspension.
Charles Amponsah Bosompem, Emmanuel Owusu Boakye came in for Yaw Wadie Darkwa and Samson Adjei Adjetey respectively.
Prince Kwabena Adu's first half goal was enough for the Hunters to clinch their very first away victory of the season.
Hafiz Wontah Konkoni hit the woodwork from the edge of the box with the first goal attempt of the game in the 12th minute.
Benedict Wobenu nearly opened the scoring for the hosts in the 18th minute but his effort from close range struck the framework.
Konkoni came very close again to put the visitors ahead but defender Samed Ibrahim made an excellent timely clearance on the goal line in the 28th minute.
A minute later the Hunters broke the deadlock through Prince Kwabena Adu as the AshantiGold defenders were caught ball watching.
Just five minutes into the second half, a begging chance fell the way of Wobenu with only the goalkeeper to beat, the striker failed to slot home.
Emmanuel Osei Baffour also came close to getting the equaliser but his attempt from close range was saved by goalkeeper Daniel Afadzwu.
AshantiGold SC will be trekking to Tarkwa to face Karela United FC on Sunday whereas Bechem United host Aduana Stars in a crunchy regional derby.