Accra Lions go on a search for a win against Gold Stars to pull further away from the relegation in a battle of the debutants.
They are currently two spots away from the cut off point in 14th place but with a three-point cushion.
Lions returned home from Bechem United empty handed after a 1-0 defeat.
They will be counting on their quite impressive home display to hand Gold Stars a defeat.
In their last two home matches, they beat Dreams FC and before that drew 0-0 with Great Olympics.
Gold Stars are in 12th placed with 26 points thanks to last week's 1-0 win over bottom-club Elmina Sharks at the Dun's Park in Bibiani.
But Michael Osei and his players will be mindful of that 5-0 defeat on the road at Asante Kotoko.
They have not fared well on the road and that could derail their survival chances.