Real Tamale United will welcome fellow strugglers Techiman Eleven Wonders to the Aliu Mahama Stadium on Sunday for the Ghana Premier League Week 31 encounter.
The two teams are separated by just two points with RTU sitting just a place above the relegation zone.
The Northern Blues are hoping to avoid a quick return to the Division One and will have to win to keep their survival hopes on course.
Real Tamale United's last victory at home was against Accra Lions, and it has been their only win in their last five matches.
While their opponents, Eleven Wonders have won two games in their last five games, losing two and drawing one.
Sunday's encounter will be keenly contested as both teams set their sights on staying up for another season, especially with three games remaining.
RTU will count on the likes of David Abagna to rediscover his goal scoring form.
Eleven Wonders can depend on the experience of the likes of Olleynu Ashitey and Isaac Kwain.
A win for RTU means they will need three more points to stay in the league but a draw keeps the relegation dogfight alive.