Ghana's Black Stars will hold their final training session at the FNB Stadium in Johannesburg on Wednesday ahead of the game against South Africa.
Per the CAF regulations, the away team is expected to train at the match venue 24 hours to kick time off.
The Black Stars arrived at the OR Tambo Airport in Johannesburg in the early hours of Wednesday after departing from Accra on Tuesday night.
The players, technical staff and management members will undergo the mandatory COVID-19 test before heading to Soweto for training.
Ghana lead Group C of the Africa Cup of Nations qualifiers, level on points with South Africa but with a superior goal difference.
The two teams are in search of a ticket to the 2021 Africa Cup of Nations scheduled for Cameroon next year.