Barcelona were held to a 0-0 draw at Huesca but Ernesto Valverde's side, with star players rested for next week's Champions League game against Manchester United, still moved 12 points clear of Atletico Madrid.
Barca, who welcomed Ousmane Dembele back after injury, gave teenage midfielder Riqui Puig a debut and also started Jean-Clair Todibo, Malcom and Carles Alena.
Huesca's Enric Gallego had an early chance, only for his control to let him down when a shooting opportunity looked to open up.
Back came Barcelona, Dembele getting away from a defender on the edge of the area but he was crowded out before he could get a shot in.
With quarter of an hour gone the visitors went even closer as Dembele was found by Puig, but his strike was saved by Roberto Santamaria, who denied Jeison Murillo from the resulting corner.
Kevin-Prince Boateng shot over as Barcelona began to take control, but clear chances were few and far between in the opening half-hour.
Ezequiel Avila was wayward from distance for the home team, and then Moussa Wague's cross from the left narrowly eluded the stretching Boateng.
Gallego fired wide after seizing on a loose ball as the first half ended goalless, with Barcelona a whisker away from breaking the deadlock early in the second when Malcom hit the post.
Huesca replaced Juanpi with Gonzalo Melero, whose first act was to get in a header that was straight at Barca keeper Marc-Andre ter Stegen, and then Juam Camilo Hernandez came on for David Ferreiro.
With 10 minutes remaining, Barcelona brought on Arthur for Alena, but they were unable to break through and survived a late penalty appeal when Chimy Avila went to ground under a Wague challenge.