Berekum Chelsea were held in check by defending champions Aduana Stars who beat  the league leaders 1-0 at the Agyeman Badu II Park in Dormaa Ahenkro on Wednesday.
Joseph Mugri's 22nd minute goal was enough to hand the three points to the home team and throw spokes into the wheels of an impressive Chelsea side.
Nonetheless, Chelsea have a 13 point lead to protect with half a dozen matches left on the calendar.
Hearts of Oak stepped up their game and distanced themselves from relegation with a slender 1-0 win over Ebusua Dwarfs in Accra.
Douglas Nkrumah struck for Hearts in the first half and sent them to a mid-table position.
Medeama Sporting Club rallied from a goal down to draw 1-1 with AshantiGold at the TNA Park.
Midfielder Theophilus Anobah registered the first goal for AshGold on seven minutes with a deflected goal.
New Edubiase thumped relegation-bound BA Stars at the Gyemfis Park with Kamil Ibrahim, Basit Adams, Ebenezer Ofori and Alhassan Nuhu.
King Faisal did little to help their relegation campaign after suffering a 3-1 defeat to Wa All Stars at the Baba Yara Stadium.
Faisal went ahead in the 9th minute through Swanzy Baffoe to end the first half 1-0.
All Stars came back strongly in the second half and levelled through Tijani Lawal in the 62nd minute.
Frank Sarfo Gyamfi added the second for All Stars in the 82nd before Tijani Lawal sealed the victory with the third.
Heart of Lions drew goalless with Mighty Jets at the Kpando Park.
Liberty Professionals needed a Michael Helegbe strike to down Berekum Arsenals 0-1 at the Golden City Park but the match was held up for close to ten minutes.
Real Tamale United held second-placed Asante Kotoko to a goalless draw in the late kick-off.