Promotion of second-tier clubs to the Ghana Premier League next season will be determined on the final day of competition after thrilling two match days.
In zone I, Bechem United thumped Bazooka FC 5-0 at the Accra Sports Stadium to move to top of the table.
United now have four points but must beat Unity FC in their last match.
Bazooka, in second place with three points, can qualify if they beat Guan United and hope the other result goes their way.
In zone III, Tema Youth stayed on top of the pack with superior goal difference after thrashing Tete Atenpong 3-0 in Sekondi.
D'International recorded a 2-0 win over King Solomon FC to remain joint leaders.
Tema Youth need a draw against D'International to secure a return to the top flight after two seasons in the second-tier league.