Kotoko will travel to Sekondi to face Proud United while rivals Hearts of Oak host second-tier Kotoku Royals after the draw for the FA Cup round of 32 was held in Accra on Wednesday.
Two-time winners Medeama host 2013 champions New Edubiase at the Tarkwa and Aboso Park.
Holders Bechem United have a relatively easy task when they host Guan United.
King Faisal battle Wassaman United with Gold Stars taking on Premier League side Elmina Sharks.
Second-tier sides FC Samartex and Asokwa Deportivo will go at each other while Young Wise host Okyeman Planners
The games have been scheduled between May 18-22, 2017
— Accra Hearts Of Oak (@HeartsOfOakGH) May 3, 2017
— Medeama SC (@MedeamaSC) May 3, 2017
Nea Salamina vs Techiman XI Wonders
Wa All Stars vs Bolga All Stars
Berekum Chelsea vs BA United
Bechem United vs Guan United
Steadfast FC vs Power SC
ZONE 2 Proud United vs Asante Kotoko
King Faisal FC vs Wassaman United
Gold Stars vs Elmina Sharks
Samatex 1996 FC vs Asokwa Deportivo
Medeama SC vs New Edubiase FC
Hearts of Oak vs Kotoku Royals
Unistar Academy vs WAFA
Liberty Professionals vs Uncle T Stars
Danbort FC vs Heart of Lions
Young Wise vs Okyeman Planners
Emmanuel FC vs Amidaus Professionals