Defender Harrison Afful received a straight red in Columbus Crew's 1-0 home defeat on Sunday to Sporting Kansas City.
In the 74th minute, Afful got sent off for pulling down Gerso Fernandes from behind on a breakaway.
Afful was making his first appearance in the MLS after a jaw injury back in March sidelined him for months.
Felipe Gutierrez, who was left unmarked, scored early in the second half with an easy header on a short cross from Gerso Fernandes.
Watch Harrison Afful speaks ahead of his return to action: