Hearts of Oak defender Karim Alhassan and Greece-based Bernard Kumordzi have earned call-ups for Ghana's friendly against Saudi Arabia on Wednesday.
The duo will replace crocked Sunderland defender John Mensah and striker Mathew Amoah for the test match to be played in Dubai.
Amoah, who got the clincher for NAC Breda in their 2-1 win over champions FC Twente, has asked to be excused before of fatigue.
Mensah picked up a shoulder injury whiles playing for Sunderland last week.
Ghana squad:
Goalkeepers: Richard Kingson (Blackpool, England), Sammy Adjei (Hearts of Oak, Ghana)
Defenders: John Paintsil (Fulham, England) Samuel Inkoom (Basel, Switzerland) Harrison Afful (Esperance, Tunisia) Lee Addy (Red Star Belgrade, Serbia) David Addy (Academica Coimbra, Portugal) Jonathan Mensah (Granada, Spain) Isaac Vorsah (Hoffenheim, Germany) Karim Alhassan (Hearts of Oak, Ghana)
Midfielders: Anthony Annan (Rosenborg, Norway), Emmanuel Agyemang-Badu (Udinese, Italy), Kwadwo Asamoah (Udinese, Italy) Andre Ayew (Marseille, France) Kevin-Prince Boateng (AC Milan, Italy) Bernard Kumordzi (Panionios FC, Greece)
Attackers: Asamoah Gyan (Sunderland, England), Emmanuel Clottey (Berekum Chelsea, Ghana) Quincy Owusu-Abeyie (Malaga, Spain)