AshantiGold achieved success on the opening day of the season after pipping Eleven Wonders FC 1-0 at away in Techiman last week.
The Miners hope to make two out of two this Saturday when they welcome Karela United FC at the Len Clay Stadium in Obuasi in a matchday two fixture.
A win over Karela will highly be appreciated by the home fans who will seeing their team for the first time this campaign.
Head coach Ernest Thompson Quartey is expected to ring some changes in his team to face the Anyinase based club this weekend.
Eric Esso who came from the bench to net the match winner against Eleven Wonders is likely to earn his first start of the season.
Quartey has a fully strength squad available to him for selection on Saturday as he eyes his first home win as trainer of AshantiGold.
Joseph Owusu Bempah, Kennedy Ashia and Joseph Amoah are in contention to make the match squad for the time in the Gold and Black colours.
After coming from behind to earn a point in the season's opener at home in Anyinase last week, Karela will try to record their first win on Saturday against AshantiGold.
Karela will play as guests in Obuasi at a venue that has been favourable to them in recent times having gone unbeaten in their last two visits.
The Pride and Passion club won 1-0 in the Special Competition in Obuasi and drew 2-2 with the Miners in the premiership last season at the Len Clay Stadium.
Diawisie Taylor who scored in both games is longer in the team after departing for the Egyptian Premier League.
Taylor was the league's top scorer last season with 18 goals and Karela are trying to fill his boots with new signing Abdul Aziz Dogo.
Dogo scored in last week's game against Aduana and will want to find the back of the net again on Saturday against AshantiGold.
Bismark Kobe Mensah has almost every player available for selection for the match.