Bottom-club Elmina Sharks face second-bottom Eleven Wonders in a relegation dogfight at the Paa Kwesi Ndoum Stadium.
Sharks are in a tight corner and it does not look like they might survive this season after escaping on the final day of competition last term.
Head coach Kobina Amissah has returned to the club he guided to the Ghana top-flight four season ago.
He faces a huge task of pulling them from the drop with 12 matches to the end of the season.
Sharks slowed glimpses of their potential when they pushed Hearts of Oak to the wall last Sunday in the MTN FA Cup.
They came from behind to take a 2-1 lead but after ten minutes of stoppage time, Sharks conceded and the match travelled to penalties.
Eleven Wonders have one win- and this was a mammoth 4-1 win at AshantiGold-since the start of the second round.
They have drawn twice against Berekum Chelsea and Kotoko and lost at Medeama.