Düsseldorf, a team once dominated by Ghanaians in its squad will no longer have one for the first time since 2019.
The German side at a point had four Ghanaians in the squad Kelvin Ofori, Kasim Nuhu Adams, Bernard Tekpetey and Opoku Ampomah in a season
The quartet have all left the club with Kelvin Ofori being the last player to exit by joining Paderborn.
Kasim Adams has joined his parent club Hoffenheim, Bernard Tekpetey completed a move to join Bulgarian giants Ludogorets last season. Opoku Ampomah has been loaned to Belgium club Royal Antwerp.
Currently the club is dominated by Japanese players in its squad for the 2021-22 season.
Shinta Appelkamp (20), Ao Tanaka (22), Takashi Usami (29) and Genki Haraguchi (30) will feature for the club this season.
Düsseldorf is placed 14th on the league table with three points after match day three.