Ghanaian giants Hearts of Oak are among seven top-flight clubs kicked out of the FA Cup.
The Porcupine Warriors suffered a shock 2-1 defeat to second-tier Asokwa Deportivo at the Len Clay stadium.
Kotoko are among seven Premier League clubs booted out from the competition.
Aduana Stars, Berekum Chelsea, Inter Allies, Ebusua Dwarfs and others have been kicked out of the competition.