Asante Kotoko face defending league champions Aduana Stars on Wednesday afternoon in the MTN FA Cup round 16 tie at the Baba Yara Stadium.
Kotoko thrashed Aduana 3-0 last month on match day 21 at the same venue and will seeking a double.
The Porcupine Warriors suffered 2-0 defeat in the corresponding fixture in November last year.
In the other fixture, Heart of Lions host New Edubiase United at the Kpando Park in another all premier league clash.