Elijah Adebayo leapt above Wycombe defender Jack Grimmer to head in Luton's third goal
Luton scored three goals in the last 10 minutes to come from behind and beat bottom-of-the-table Wycombe, who played most of the second half with 10 men.
The hosts went ahead when Admiral Muskwe was brought down in the box by Kal Naismith, and Anis Mehmeti's penalty had the power to beat Simon Sluga.
Wycombe's Josh Knight was shown a straight red card for a lunge on Jordan Clark and the Hatters eventually levelled through George Moncur's 25-yard free-kick into the bottom corner.
Kazenga LuaLua put Luton ahead with an excellent curling effort from a short corner, and Elijah Adebayo sealed the points with a brilliant header from Harry Cornick's cross.
- Relive Saturday's EFL action
A first defeat in four for Gareth Ainsworth's Chairboys left them nine points from safety with only five games left, while it was a first win in three for the mid-table visitors.
The teams observed a two-minute silence and wore black armbands in memory of Prince Philip, who died on Friday aged 99.
Wycombe had a strong penalty appeal waved away when Uche Ikpeazu was brought down by Matty Pearson, but when referee Oliver Langford did point to the spot for Naismith's challenge, Mehmeti found the net, despite Sluga getting a hand to it.
It was one-way traffic after Knight's dismissal, but the home side dug deep in search of a fifth clean sheet in six games.
But fine finishes from substitutes Moncur and LuaLua - plus Adebayo's towering header - turned the tables.
Luton, who sit 13th, have gone 14 away matches without losing at Wycombe in the top four tiers - the best such record for any team in Football League history.
- Line-upsMatch StatsLive Text
Line-upsWycombe
Formation 3-5-2
31Stockdale2Grimmer5Stewart12Knight26McCarthy33Mehmeti24Adeniran18Thompson23Onyedinma15Muskwe9Ikpeazu
- 31Stockdale2Grimmer5Stewart12KnightBooked at 57mins26McCarthy33MehmetiBooked at 56minsSubstituted forWheelerat 62'minutes24Adeniran18Thompson23Onyedinma15MuskweSubstituted forAkinfenwaat 84'minutes9IkpeazuSubstituted forSamuelat 78'minutes
Substitutes
- 1Allsop7Wheeler8Pattison11Kashket16Phillips17Horgan19McCleary20Akinfenwa25Samuel
Luton
Formation 4-1-2-1-2
12Sluga26Bree6Pearson5Bradley24Naismith17Mpanzu4Tunnicliffe18Clark8Berry19Collins29Adebayo
- 12Sluga26BreeSubstituted forLuaLuaat 54'minutes6PearsonSubstituted forMoncurat 77'minutes5BradleyBooked at 31mins24Naismith17Mpanzu4TunnicliffeSubstituted forDewsbury-Hallat 45'minutes18Clark8BerrySubstituted forCornickat 45'minutes19CollinsSubstituted forReaat 90+2'minutes29Adebayo
Substitutes
- 1Shea2Cranie7Cornick14Moncur16Rea22Dewsbury-Hall25LuaLua27Nombe28Morrell
Referee:Oliver LangfordMatch StatsHome TeamWycombeAway TeamLutonPossessionHome36%Away64%ShotsHome7Away13Shots on TargetHome4Away6CornersHome4Away3FoulsHome10Away12Live TextPost update
Match ends, Wycombe Wanderers 1, Luton Town 3.
90'+6'Full Time
Second Half ends, Wycombe Wanderers 1, Luton Town 3.
90'+5'Post update
Foul by Kiernan Dewsbury-Hall (Luton Town).
90'+5'Post update
Curtis Thompson (Wycombe Wanderers) wins a free kick in the attacking half.
90'+3'Post update
Foul by George Moncur (Luton Town).
90'+3'Post update
Curtis Thompson (Wycombe Wanderers) wins a free kick on the right wing.
90'+2'Substitution
Substitution, Luton Town. Glen Rea replaces James Collins.
90'Post update
Attempt saved. Adebayo Akinfenwa (Wycombe Wanderers) header from the centre of the box is saved in the bottom left corner. Assisted by Jason McCarthy with a cross.
89'Post update
Harry Cornick (Luton Town) wins a free kick in the defensive half.
89'Post update
Foul by Alex Samuel (Wycombe Wanderers).
88'goalGoal!
Goal! Wycombe Wanderers 1, Luton Town 3. Elijah Adebayo (Luton Town) header from very close range to the high centre of the goal. Assisted by Harry Cornick with a cross.
86'Post update
Attempt blocked. Alex Samuel (Wycombe Wanderers) right footed shot from the right side of the box is blocked.
86'Post update
Attempt missed. Elijah Adebayo (Luton Town) left footed shot from the centre of the box is too high. Assisted by Pelly-Ruddock Mpanzu.
85'goalGoal!
Goal! Wycombe Wanderers 1, Luton Town 2. Kazenga LuaLua (Luton Town) right footed shot from outside the box to the top right corner. Assisted by George Moncur following a corner.
84'Substitution
Substitution, Wycombe Wanderers. Adebayo Akinfenwa replaces Admiral Muskwe.
84'Post update
Corner, Luton Town. Conceded by Jason McCarthy.
81'Post update
Attempt saved. Alex Samuel (Wycombe Wanderers) left footed shot from outside the box is saved in the bottom right corner. Assisted by Curtis Thompson with a headed pass.
80'goalGoal!
Goal! Wycombe Wanderers 1, Luton Town 1. George Moncur (Luton Town) from a free kick with a right footed shot to the bottom right corner.
79'Post update
Jordan Clark (Luton Town) wins a free kick in the attacking half.
79'Post update
Foul by Jack Grimmer (Wycombe Wanderers).
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Source: bbc.com