Karela United will host Techiman Eleven Wonders on Sunday on matchday 25 of the Ghana Premier League.
The Anyinase Boys return to the Crosby Awuah Park after a vital away point at Elmina Sharks in midweek.
Coach Evans Adotey and his boys will count on home support as they seek another win at their fotress in Anyinase.
Meanwhile, Techiman Eleven Wonders are unbeaten in their last three games, and have just lost a game in their last eight matches.
The Techiman based club are currently 15th on the table and two points above the relegation places.
A defeat in Anyinase will dent their hopes of survival but Eleven Wonders will count on the success of their previous game against Karela.
Eleven Wonders won 3-1 when the two sides met at the Ohene Ameyaw Park in the first round.
But they've lost Man of the Match in that game Salifu Ibrahim to Hearts of Oak, leaving them with Derrick Okraku and Maxwell Boakye to rely on to produce the magic.
Diawisie Taylor, who leads the goal scorers chat with 13 goals is yet to produce his goal scoring prowess in the second round.
Karela United have dropped to fifth after just a win since the resumption of the league.
Prediction: Karela United 1-1 Eleven Wonders