Dreams FC, after an astonishing victory over AshantiGold in match day 7 on the road last Sunday, will test the might of Asante Kotoko.
Emmanuel Lomotey is expected to return to the Dreams FC side after missing the last Sunday's match through illness.
Midfielder Prosper Donkor looks doubtful for Asante Kotoko's visit.
Godwin Horlali and Alhassan Kalusha are still in the recovering process and are out of the super clash on Wednesday.
Asante Kotoko will continue their journey of getting back to winning ways with interim coach Michael Osei.
Felix Annan is available for selection ahead of the midweek fixture against Dreams FC at the Dawu Park despite training last week after after a month lay off through injury.
Jackson Owusu has been ruled out of the season.
Asante Kotoko have recorded two straight emphatic victories against Liberty Professionals and Real 24 Hours FC in Kumasi and Tumu respectively before their trip to Dawu.
MATCH FACTS
Total matches played = 0
Dreams FC wins = 0
Drawn matches = 0
Asante Kotoko wins = 0
*This will be the first premier league meeting of the two clubs in the Ghana Premier League history.
*Dreams FC have lost only once in their maiden campaign in the Ghanaian top flight after seven games.
(W4 D2 L1)
*Asante Kotoko have recorded two victories in their seven matches they have played in the league this season.
(W2 D2 L3)
*Dreams FC are unbeaten at home in the premier league this season after three matches.
(W2 D1 L0)
*Asante Kotoko have won just two of their last six away fixtures in the league.
They have lost all their away games this season.
(W2 D1 L3)
*The premier league debutants have managed to keep clean sheets in their last two matches in the league this season.
They have conceded just one goal at home so far.
*Asante Kotoko have conceded in all of their premier league outings this term.
They have failed to score at away in the league.
By Nuhu Adams