Saints last reached the FA Cup final in 2003
Southampton's FA Cup third-round tie at home to Shrewsbury has been rescheduled for Tuesday, 19 January.
The match was initially due to be played last Saturday, but was postponed after a number of positive Covid-19 tests at the League One club.
The winner will host Arsenal in the fourth round, due to take place on the weekend of 23-24 January.
Southampton's Premier League visit to Leeds on 20 January will be moved, with a new date to be announced.
The Premier League said any future FA Cup rescheduling decisions involving Premier League teams would be "assessed on a case-by-case basis".
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Source: bbc.com