São Tomé and Principé have booked a place in the 2021 Africa Cup of Nations qualifications group stages and will be in the same group with Ghana.
São Tomé impressively beat Mauritius 2-1 on Sunday to advance on a 5-2 aggregate.
Portugal based Marcos Barbeiro gave the Falcons and Parrots the lead before captain Luiz Leal added the second.
São Tomé are joining Ghana, South Africa and Sudan in Group C to battle for the two slots for the flagship tournament in Cameroon.
The Black Stars will travel to face São Tomé a week after hosting South Africa in the opener.
Ghana's last qualifying fixture will be against São Tomé at home in November next year.