Defender Kyle Walker-Peters produced a moment of magic to lift Southampton fans following the departure of striker Danny Ings.
The £30million transfer of Ings to Aston Villa was announced just before kick-off at a subdued St Mary's on Wednesday night.
Ings has scored 46 goals in 100 appearances for Southampton after joining from Liverpool in 2018.
Midfielder James Ward-Prowse, who has also been linked with a move to Villa Park, was not in the match-day squad on Wednesday night.
Southampton started brightly and enjoyed plenty of possession but it was the visitors who went closest to breaking the deadlock in the first-half.
Walker-Peters put the home side ahead just after the hour mark.
Walker-Peters darted down the right and after a couple of step overs, fired a superb shot across goal into the bottom corner.