US-born Ghanaian, Yunus Musah, is set to miss Valencia's clash against Celta Vigo in La Liga on Saturday.
The midfielder picked a knock during training on Thursday and has not trained since, making him a doubt for tonight's match.
Manager Genaro Gattuso is unsure if he will be ready for the Celta Vigo game.
"He had a little discomfort. It's not a big thing, but today he hasn't trained. I'll talk to the doctor later but on a clinical level he has a small injury. No I know if he will be in the game, but today he has not trained with us," he said in a pre-match conference.
The injury could affect Musah's return to the US national team for the friendlies against Japan and Saudi Arabia later this month.
"I like it when players from my team go to the national team because they are playing more. We have five players who are going at the moment because Cavani is not going. He has been talking to the coach. Also Musah if it is confirmed that he has an injury," Gattuso added.