Medeama put Asante Kotoko to flight with a 1-0 win at the T&A Park in Tarkwa on Thursday in the Special Competition.
The Mauve and Yellows were awarded a penalty in the 35th minute after Kotoko defender Abass Mohammed blocked a goal bound header on the line with his hand.
Referee Maxwell Hansen pointed to the spot for a penalty and also flashed the straight red card on the left back.
Striker Kwame Boateng converted a first half penalty to punish his former side on on a rain-soaked pitch.
Medeama were playing their first match in the competition after their opener against Berekum Chelsea was postponed.