Ghana coach Kwasi Appiah is set to alternate his squad when his team play against Guinea-Bissau on Tuesday in the final group game of the 2019 Africa Cup of Nations because of a suspension and injuries.
The Black Stars will need to win the game at all cost to enhance their chances of progressing out of the group.
But the side will be without key player Christian Atsu who picked up an injury and substituted in the game against Cameroon has been ruled out of the tournament.
He will miss the encounter along with Thomas Agyepong who is nursing his injury after being taken in the opening match against Benin while Jonathan Mensah has also suffered a injury setback
Kassim Nuhu Adams will also miss due to suspension.
Ghana are without a win in thier last two games played after drawing against Benin and Cameroon.
Appiah made three changes to his starting line up against Cameroon on Saturday and will be forced to make changes to his squad when Ghana play Guinea Bissau in Sues.
Samuel Owusu is likely to make a start while John Boye who missed the second game against Cameroon due to suspension is expected to take the place of Kassim Nuhu.