Ebusua Dwarfs and Legon Cities clash in CapeCoast in what is expected to be a tight contest as the teams need the three points at stake.
Dwarfs are four points from safety and want to extend it while Legon Cities are in the relegation zone.
This could be Bashir Hayford's last game as reports indicate the club has reached an agreement with Maxwell Konadu to take charge as head coach.
The two teams come into the game on the back of defeats to title contenders.
Dwarfs suffered a 3-0 loss at the hands of Medeama while Legon Cities were beaten 1-0 at home by Kotoko.
Dwarfs go the better of Cities in the first meeting of the season as they won 2-1 in Accra.
Prediction: Ebusua Dwarfs 2-1 Legon Cities