Striker Abdul Majid Waris scored in Hacken's 3-2 loss to Helsinborg in the Swedish top-flight and Christian Atsu was on target for Rio Ave in the Portuguese League.
Others Ghanaian players won slots to play in Europe next season and few suffered relegation.
ENGLAND
Michael Essien played the full time for Chelsea who defeated relegated Blackburn Rovers 2-1 at the Stamford Bridge in the final day of the English Premier League.
Essien set up the match winner for Chelsea by assisting Raul Meireles.
In the League One play-off, QPR loanee Patrick Agyemang played the entire match for Stevenage who were held to a 0-0 draw by Sheffield United.
ITALY
Udinese secured a Uefa Champions League spot after beating Catania 2-0 at their own backyard.
Ghana midfielder Kwadwo Asamoah played the entire match for Udinese but Emmanuel Agyemang-Badu was not named in Udinese team.
Three Ghanaian youngsters were named in the Fiorentina team that drew 0-0 with Cagliari at the Stadio Artemio Franchi.
Midfielder Amidu Salifu was introduced in the 17th minute mark to replace the injured Marchionni while striker Maxwell Boadu Acosty played the last 26 minutes.
Defensive midfielder Daniel Kofi Agyei warmed the bench.
Kevin-Prince Boateng was forced out of AC Milan's 2-1 win over Novara due to injury in the 10th minute.
The Black Stars midfielder Sulley Muntari has already been ruled out for four weeks and watched the game from the stands.
In the Serie B, 17-year-old Ghanaian midfielder Mase Nana Addo Welbeck played 24 minutes for Brescia who drew 2-2 at Bari.
Yaw Asante played 55 minutes for Grosseto who lost 2-1 at Modena.
AS Roma loanee Ahmed Ampimah Barusso was suspended for Nocerina who lost 3-1 at Crotone.
Striker Richmond Boakye-Yiadom lasted 50 minutes for Sassuolo who drew 0-0 at Livorno.
Midfielder Isaac Cofie was left out of the Sassuolo team.
SPAIN
Wakaso Mubarak played the last six minutes for Villarreal who lost 1-0 on home soil against Atletico Madrid.
FRANCE
Defender John Boye warmed the bench for Stade Rennes who lost 3-0 at PSG.
Midfielder Rabiu Mohammed played full-throttle for Evian Thonon Gaillard who held OG Nice to a 1-1 draw.
Jordan Ayew played 70 minutes for Olympique Marseille who thrashed Auxerre 3-0.
Bernard Yao Kumordzi was featured in a midfield scrapper role for Dijon who drew 1-1 against Toulouse.
Jerry Vandam played at right-back for Caen who suffered a 3-1 loss against Sochaux.
In the Ligue 2, Moussa Narry was left out of the Le Mans first team squad that lost 2-1 at Tours.
Metz recorded a 1-0 loss at Arles Avignon.
Ghana youth striker Kwame Nsor lasted 72 minutes for Metz while Haminu Dramani came off the bench to play 69 minutes for Arles.
Dennis Appiah did not feature in AS Monaco's 2-0 loss at Troyes.
SWITZERLAND
Ghana winger Ishmael Yartey played an influential role for FC Servette in their 1-0 win at FC Zurich.
PORTUGAL
Christian Atsu Twasam scored for Rio Ave in their 5-2 defeat to FC Porto in the Portuguese top-flight.
USA
Dominic Oduro scored the winner for Chicago Fire who defeated Sporting Kansas City 2-1. Compatriot Patrick Nyarko also played full time for Fire.
Gershon Koffie lasted 80 minutes for Vancouver Whitecaps who lost 4-1 at New England Revolution.
SWEDEN
Striker Abdul Majeed Waris scored his sixth goal of the season for Hacken who lost 3-2 Helsingborg.
The 20-year-old scored on the 58th minute mark and was replaced after 69 minutes. Swedish-born Ghanaian defender Joseph Baffo warmed the bench for Helsingborg.
Degerfors suffered their fifth defeat of the season after losing 1-0 at Varberg.
AIK Stockholm loanee Kwame Amponsah Karikari played the full match for Degerfors while defender Kassenu Ghandy played the last 21 minutes.
DENMARK
In the second-tier, Viborg moved to fourth place despite drawing 1-1 with Hobro.
Former Ghana striker Razak Pimpong and youngster Jeff Mensah both played the entire duration for Viborg.
NORWAY
King Osei Gyan did not feature in Viking's 2-1 victory at Sogndal.
Stromsgodset surrendered their leadership of the league after losing 3-1 at Aalesund.
Ghana trio Adam Kwarasey, Mohammed Abu and Razak Nuhu played the entire match for Stroms.
Former Ghana U17 skipper Paul Addo played in central midfield for Odd Grenland and helped them to defeat Honefoss 4-1.
In the second-tier, winger Ernest Asante scored the only goal of the match for IK Start who beat Kongsvinger 1-0 to move to third place.