Several windows of the 52-seater Benz was smashed by objects, including a bottle and stones, hurled at the vehicle.
The bus had been packed inside the Crossby Awuah Memorial Park with irate fans having a field day in damaging the vehicle.
It appears the military men detailed at the venue failed to control the crowd after the fans went bonkers in full glare of the security apparatus.
The fans vented their spleen on the visiting team, hitting midfielder Eric Kwakwa with a missile just after the break.
They took their action outside the pitch to damage the windows on the bus in an extraordinary scenes at the CAM park.
The match has been overshadowed by massive crowd violence which has rocked the famous Cup competition.
Prince Opoku Agyemang opened the scoring in the first half, capitalizing on a defensive howler to give the visitors the lead.
Ebenezer Ackahbi increased the tally with a superb finish before Diawisie Taylor pulled one back for the visitors.
However, its the massive crowd trouble which has gained inches in the local media with a reported irage siege by the home fans.
Referee Philip Arthur-Forson was forced to delay the match on two occasions following the marauding attacks from the home fans.
Medeama midfielder Eric Kwakwa was hit with a stone as he made his way to the tunnel after the first half.
Military men detailed at the venue are had a torrid time to control the home supporters in a highly volatile atmosphere at Aiyinase.
The match was held up several times with fans throwing missiles onto the pitch.
The military has been forced onto the pitch to protect life and property in what has been a an extraordinary scenes at Aiyinase.
Some journalists were denied entry into the stadium with the game delayed closed to 30 minutes into the second half.