Ivan Toney has scored 17 goals in 26 appearances across all competitions for Brentford this season
Ivan Toney scored one and assisted another as Brentford boosted their European hopes and heaped further misery on bottom club Southampton with a win at St Mary's.
Toney tapped in Christian Norgaard's flick-on after a Bryan Mbeumo corner in the 32nd minute.
And in second-half injury-time his header sent through Yoane Wissa who calmly doubled the visitors' lead.
Victory saw the Bees move up to eighth in the Premier League table.
Southampton stay 20th, two points off safety having played one game more than most of their relegation rivals.
Saints' best opportunity for an equaliser came shortly after the restart with Brentford defender Aaron Hickey blocking a Che Adams effort when keeper David Raya was beaten.
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Toney impresses on eve of England squad announcement
Toney produced a match-winning performance less than 24 hours before England manager Gareth Southgate will announce his squad for two European Championship qualifiers this month.
Uncapped Toney, 26, is the second-highest English goalscorer in the Premier League this season, having scored four fewer than Tottenham's Harry Kane and two more than Manchester United's Marcus Rashford.
His opener was a true striker's finish, meeting a header at the back post to poke the ball into an empty net.
It was just what Brentford deserved, rounding off a first half where Kevin Schade had gone close with a looping header.
The Bees sat back after the restart, adding another in the closing stages to complete a league double over Southampton for the first time since the 1958-59 season.
Victory saw them move to within one point of the top six, leapfrogging west London rivals Fulham up to eighth.
Drab Saints stay rock bottom
Such is the tightness of this season's Premier League relegation battle, victory would have ensured Southampton ended the day outside of the relegation zone for the first time since 5 November.
Instead they looked flat in the first half, unable to follow up their goalless draw with Manchester United on Sunday with another positive result.
Adams' effort following a Kyle Walker-Peters cutback was one of very few clear-cut chances for Ruben Selles' side.
Southampton's loss was their 17th in the league this season, having only tasted defeat 16 times last campaign.
They host Tottenham in their next match on Saturday (15:00 GMT), while Brentford are at home to Leicester City at the same time.
Player of the match
ToneyIvan Toney
with an average of 7.86
- SouthamptonSouthamptonSouthamptonBrentfordBrentfordBrentford
SouthamptonAvgSquad number8Player nameWard-ProwseAverage rating
5.65
Squad number31Player nameBazunuAverage rating
5.54
Squad number2Player nameWalker-PetersAverage rating
5.46
Squad number10Player nameAdamsAverage rating
5.11
Squad number26Player nameAlcarazAverage rating
5.10
Squad number15Player namePerraudAverage rating
4.99
Squad number37Player nameBella-KotchapAverage rating
4.93
Squad number20Player nameSulemanaAverage rating
4.84
Squad number35Player nameBednarekAverage rating
4.83
Squad number27Player nameDialloAverage rating
4.42
Squad number24Player nameElyounoussiAverage rating
4.34
Squad number45Player nameLaviaAverage rating
4.16
Squad number32Player nameWalcottAverage rating
4.00
Squad number12Player nameOnuachuAverage rating
3.73
Squad number14Player nameBreeAverage rating
3.54
BrentfordAvgSquad number17Player nameToneyAverage rating
7.86
Squad number24Player nameDamsgaardAverage rating
7.85
Squad number11Player nameWissaAverage rating
7.74
Squad number2Player nameHickeyAverage rating
7.60
Squad number18Player nameJanssonAverage rating
7.46
Squad number1Player nameRayaAverage rating
7.31
Squad number6Player nameNørgaardAverage rating
7.31
Squad number16Player nameMeeAverage rating
7.17
Squad number8Player nameJensenAverage rating
7.16
Squad number3Player nameHenryAverage rating
7.07
Squad number15Player nameOnyekaAverage rating
7.03
Squad number5Player namePinnockAverage rating
6.98
Squad number9Player nameSchadeAverage rating
6.96
Squad number19Player nameMbeumoAverage rating
6.95
Squad number27Player nameJaneltAverage rating
6.81
- Line-upsMatch StatsLive Text
Line-upsSouthampton
Formation 4-2-3-1
31Bazunu2Walker-Peters35Bednarek37Bella-Kotchap15Perraud8Ward-Prowse27Diallo24Elyounoussi26Alcaraz20Sulemana10Adams
- 31Bazunu2Walker-PetersSubstituted forBreeat 59'minutes35BednarekBooked at 90mins37Bella-Kotchap15Perraud8Ward-Prowse27DialloSubstituted forLaviaat 58'minutes24ElyounoussiSubstituted forWalcottat 58'minutes26AlcarazSubstituted forOnuachuat 66'minutes20Sulemana10Adams
Substitutes
- 9A Armstrong12Onuachu13Caballero14Bree17S Armstrong18Mara22Salisu32Walcott45Lavia
Brentford
Formation 4-3-3
1Raya2Hickey5Pinnock16Mee3Henry8Jensen6Nørgaard27Janelt19Mbeumo17Toney9Schade
- 1Raya2HickeyBooked at 79mins5Pinnock16Mee3Henry8JensenSubstituted forDamsgaardat 79'minutes6Nørgaard27JaneltSubstituted forOnyekaat 45+1'minutes19MbeumoSubstituted forJanssonat 78'minutes17ToneyBooked at 90mins9SchadeSubstituted forWissaat 65'minutes
Substitutes
- 10Dasilva11Wissa13M Jorgensen14Ghoddos15Onyeka18Jansson24Damsgaard26Baptiste34Cox
Referee:Michael SalisburyMatch StatsHome TeamSouthamptonAway TeamBrentfordPossessionHome67%Away33%ShotsHome7Away11Shots on TargetHome1Away5CornersHome3Away3FoulsHome14Away10Live Text Post update
Match ends, Southampton 0, Brentford 2.
90'+9'Full Time
Second Half ends, Southampton 0, Brentford 2.
90'+7'goalGoal!
Goal! Southampton 0, Brentford 2. Yoane Wissa (Brentford) right footed shot from the centre of the box to the bottom right corner. Assisted by Ivan Toney with a headed pass.
90'+5'Post update
Foul by Che Adams (Southampton).
90'+5'Post update
Yoane Wissa (Brentford) wins a free kick in the defensive half.
90'+4'Post update
Offside, Southampton. Kamaldeen Sulemana tries a through ball, but Che Adams is caught offside.
90'+4'Post update
Attempt missed. Kamaldeen Sulemana (Southampton) right footed shot from the left side of the box misses to the right. Assisted by Che Adams.
90'+3'Booking
Jan Bednarek (Southampton) is shown the yellow card.
90'+3'Booking
Ivan Toney (Brentford) is shown the yellow card.
90'+2'Post update
Delay over. They are ready to continue.
90'+2'Post update
Attempt saved. Mikkel Damsgaard (Brentford) right footed shot from outside the box is saved in the bottom left corner.
90'+1'Post update
Che Adams (Southampton).
90'+1'Post update
Christian Nørgaard (Brentford) wins a free kick in the defensive half.
90'Post update
Foul by Roméo Lavia (Southampton).
90'Post update
Christian Nørgaard (Brentford) wins a free kick on the left wing.
86'Post update
Delay over. They are ready to continue.
83'Post update
Delay in match because of an injury Pontus Jansson (Brentford).
83'Post update
Attempt blocked. Romain Perraud (Southampton) left footed shot from outside the box is blocked. Assisted by Kamaldeen Sulemana.
82'Post update
Corner, Southampton. Conceded by Ben Mee.
80'Post update
Foul by James Ward-Prowse (Southampton).
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Source: bbc.com