England midfielder Dele Alli was one of the senior players in the Spurs side
Tottenham paid the price for leaving their star players at home as Dutch side Vitesse Arnhem earned a deserved win in the Europa Conference League.
Vitesse left-sided midfielder Maximillian Wittek crisply converted from the edge of the area, dealing a blow to the visitors' hopes of progressing comfortably from Group G.
With key players including Harry Kane and Son Heung-min rested, Spurs fielded a different starting XI to the one who beat Newcastle in the Premier League on Sunday and they lacked rhythm in a poor performance.
The Dutch side, who finished fourth in the Eredivisie last season, created the better opportunities and delighted a sell-out crowd when Wittek finally made their dominance count.
Spurs hit the bar through Bryan Gil moments after half-time but rarely threatened afterwards and finished the match having managed just one shot on target.
The defeat means Nuno Espirito Santo's side are third at the halfway stage of Group G, having drawn with French side Rennes and thrashed Slovenian minnows Mura in their opening two games.
Only the group winner automatically goes through to the last 16 in Europe's third-tier club competition.
- Reaction to Vitesse v Tottenham before West Ham host Genk in the Europa League
- Line-upsMatch StatsLive Text
- 1Schubert3Doekhi10Bazoer6Rasmussen2Dasa21BeroBooked at 12mins8Tronstad32WittekBooked at 81minsSubstituted forHajekat 87'minutes11Baden FrederiksenSubstituted forBuitinkat 85'minutesBooked at 89mins9Darfalou7OpendaSubstituted forOrozat 90+1'minutes
- 16Oroz18Hajek19von Moos20Gboho22Domgjoni24Houwen27Yapi29Buitink36Vroegh39Cornelisse40Huisman48van Haveren
22Gollini25Tanganga6D Sánchez14Rodon33Davies18Lo Celso8Winks11Gil20Alli23Bergwijn44Scarlett
- 22Gollini25Tanganga6D SánchezBooked at 72mins14Rodon33Davies18Lo Celso8WinksBooked at 80mins11Gil20Alli23BergwijnBooked at 41mins44ScarlettBooked at 74minsSubstituted forMarkandayat 75'minutes
Referee:Harm OsmersAttendance:23,931Match StatsHome TeamVitesseAway TeamTottenhamPossessionHome47%Away53%ShotsHome15Away6Shots on TargetHome4Away1CornersHome5Away2FoulsHome14Away20Live TextPost update
Match ends, Vitesse 1, Tottenham Hotspur 0.
Second Half ends, Vitesse 1, Tottenham Hotspur 0.
Attempt blocked. Harry Winks (Tottenham Hotspur) right footed shot from outside the box is blocked. Assisted by Steven Bergwijn.
Giovani Lo Celso (Tottenham Hotspur) wins a free kick on the left wing.
Foul by Oussama Darfalou (Vitesse).
Substitution, Vitesse. Alois Dominik Oroz replaces Loïs Openda.
Thomas Buitink (Vitesse) is shown the yellow card.
Joe Rodon (Tottenham Hotspur) wins a free kick in the defensive half.
Foul by Thomas Buitink (Vitesse).
Substitution, Vitesse. Tomas Hajek replaces Maximilian Wittek.
Foul by Joe Rodon (Tottenham Hotspur).
Oussama Darfalou (Vitesse) wins a free kick in the defensive half.
Substitution, Vitesse. Thomas Buitink replaces Nikolai Baden Frederiksen.
Foul by Dele Alli (Tottenham Hotspur).
Matús Bero (Vitesse) wins a free kick in the defensive half.
Attempt missed. Nikolai Baden Frederiksen (Vitesse) left footed shot from outside the box is too high. Assisted by Loïs Openda following a fast break.
Maximilian Wittek (Vitesse) is shown the yellow card for a bad foul.
Dilan Markanday (Tottenham Hotspur) wins a free kick on the right wing.
Foul by Maximilian Wittek (Vitesse).
Harry Winks (Tottenham Hotspur) is shown the yellow card.
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