Jordan Ayew was on target in the French Ligue 1 on Sunday; Emmanuel Clottey and Uriah Asante also found the back of the net in Tunisia.
In the Italian Serie B, Richmond Boakye-Yiadom scored twice for Sassuolo on Saturday.
Ghana striker Asamoah Gyan scored a double on Friday for Al Ain in the United Arab Emirates Etisalat Pro League.
Here is a comprehensive wrap of how Ghanaian players abroad fared.
Arsenal loanee Emmanuel Frimpong made his debut for Charlton Athletic after playing 65 minutes in their 1-1 draw with Huddersfield Town on Saturday.
Winger Albert Adomah scored the opener for Bristol Rovers who shocked Middlesbrough with a 3-1 win.
Jeffrey Schulpp played full throttle for Leicester City who posted a 2-0 win over Sheffield Wednesday at their own backyard.
In the League One, former QPR striker Patrick Agyemang came off the bench to play 17 minutes for Stevenage in their 1-1 draw with leaders Tranmere Rovers.
Former Liverpool Academy graduate David Amoo was an unused substitute by Preston North End who lost 2-0 at Leyton Orient.
In the League Two, Andy Yiadom played the entire match for Barnet as they suffered a 1-0 loss at Cheltenham Town.
In the Bundesliga II, former Ghana U17 striker Kwame Nsor watched from the bench as his Kaiserslautern beat FSV Frankfurt 1-0.
St Pauli boosted their promotion hopes with a 4-1 win over MSV Duisburg.
German-born Ghanaian defender Christopher Avevor set up the opening goal for Pauli while American-born Joseph Claude-Gyau played 64 minutes for Pauli.
In the Liga 3, Arminia Bielefeld moved to third place after beating Wacker Burghausen 3-0. Former AshGold striker Eric Agyemang warmed the bench for Bielefeld.
Phil Ofosu-Ayeh played full 90 minutes for Rot-Weiß Erfurt drew 1-1 with Hansa Rostock.
Palermo condemned Catania to a 3-1 defeat at the Stadio Renzo Barbera.
Former Fiorentina midfielder Amidu Salifu warmed the bench once more for Catania.
Former Inter Milan academy striker Said Ahmed Said made his way into the Genoa first team squad but sat on the bench as they beat Atalanta 1-0.
Isaac Cofie came off the bench to play 14 minutes for ten-man Chievo Verona who played a goalless stalemate with Siena at the Stadio Marc'Antonio Bentegodi.
AC Milan did the unthinkable by beating Juventus 1-0 at the San Siro.
Midfielder Kwadwo Asamoah played 72 minutes for Juventus while Kevin-Prince Boateng lasted 84 minutes for Milan.
Sulley Muntari missed the game due to injury.
In the Serie B, Ahmed Ampimah Barusso played the entire 90 minutes and was booked in the 79th minute when his Novara side lost 1-0 to Livorno.
Parma loanee Bright Addae watched from the Crotone bench as they lost 1-0 to Padova.
Maxwell Acosty played 90 minutes and was booked in the 49th minute as his Juve Stabia side lost 2-1 to Empoli.
Daniel Kofi Agyei failed to win the fitness battle for the game.
Striker Richmond Boakye-Yiadom grabbed a brace for Sassuolo in their 3-1 win over Reggina.
Midfielder Yussif Raman Chibsah came off the bench to play 16 minutes for Sassuolo.
Wakaso Mubarak played full throttle but could not help his Espanyol side avoid 2-0 defeat at the hands of Getafe.
Midfielder Anthony Annan watched from the bench as his Osasuna side held Real Sociedad to a 0-0 draw.
In the Segunda B, young midfielder Thomas Partey was in full time action for Atletico Madrid B as they held Fuenlabrada to a 0-0 draw.
Midfielder Paul Quaye set up the second goal for Espanyol B in their 2-2 with Ontinyent.
Jordan Ayew scored the only of the game for Marseille as they beat ten-man Lille 1-0 to reclaim second spot.
Ishmael Yartey was rested by Sochaux who lost at home to OG Nice.
Evian TG ended Stade Rennes' four-match winning run by beating them 1-0 at the Stade de Route de la Lorient.
Defender John Boye was at the heart of defence for Rennes while Rabiu Mohammed played 66 minutes for Evian.
In the Ligue 2, Haminu Dramani was axed from the Arles first team squad as they beat Istres 1-0 at their own backyard.
ADO Den Haag smoothly edged NAC Breda 3-0. Young striker Kevin Tano was an unused substitute.
Nana Akwasi Asare played the full 90 minutes for ten-man FC Utrecht who lost 2-0 to NEC.
Matthew Amoah was excluded from the Heerenveen team that held VVV Venlo to a 1-1 draw.
Kwame Quansah was booked in the 56th minute and played 90 minutes for Heracles Almelo in their 2-2 against Willem II.
Memphis Depay watched from the bench as his PSV Eindhoven lost 2-1 to on-fire Vitesse Arnhem at the Philips Arena.
Young winger Edwin Gyasi played 58 minutes for FC Twente who drew 2-2 with PEC Zwolle who had Fred Benson in their starting line-up.
In the second-tier league, Jonathan Opoku scored the second goal for Veendam who beat Excelsior 3-2.
Compatriot Mitch Apau was sent off in the 52nd minute. Elvis Manu also played 90 minutes for Excelsior.
Dutch-born Mawouna Kodjo Amevor was received a straight red card as his Dordrecht lost 3-0 to Sparta Rotterdam.
Former Hearts of Oak defender Karim Alhassan was a full timer for Adana Demirspor who beat Gaziantep BB 2-1.
Standard Liege ended their two game winless run with a 3-0 win over SK Lierse.
Rahim Ayew played full time for Lierse but Cofie Bekoe saw the action from the bench. Abraham Kudemor was in action for Sporting Charleroi who finished with ten men against Club Brugge.
KV Mechelen were shocked at home by struggling Waasland-Beveren who beat them 1-0. Abdul Yakinu Iddi played 65 minutes for Mechelen.
In the Second Division, Samuel Asamoah helped AS Eupen to beat Oudenaarde 3-2.
Former AshGold striker Shaibu Yakubu was replaced on the 90th minute mark as his Enosis side managed to hold Ethnikos Achna to a 0-0 draw.
Alki and Nea Salamis shared the spoils in a 1-1 draw.
Young attacker Gerome Agbo sat on the Salamis bench while Carlos Ohene came off the bench to play 1 minute for Alki. Yussif Rahman also sat on the bench.
Esbjerg handed Nordsjælland their second straight defeat of the season after beating them 1-0.
Midfielder Enock Adu Kofi did not make the trip with Nordsjælland but youngster Kamal Issah sat on the bench.
Former St Pauli defender Davidson Drobo-Ampem was an unused sub by Esbjerg.
Manchester City loanee Thomas Agyiri sat on the bench Gil Vicente as they drew 2-2 with Academica.
Defender David Addy played at left-back for Vitória Guimaraes who returned from Beira-Mar with a 2-2 draw.
In the second-tier league, former Cheetah FC midfielder Alhassan Wakaso was absent from the Portimonense squad as they drew 1-1 with Naval 1º de Maio.
Astra Giurgiu out muscled Pandurii Târgu Jiu 4-1 to consolidate their second place.
Midfielder Seidu Yahaya played full throttle for Astra Giurgiu but striker Sadat Bukari was unused.
Veteran attacker Godwin Attram played 65 minutes for AL Hajer who lost 2-1 to Al Shabab.
Former All Stars midfielder Frank Sarfo-Gyamfi came off the bench to score for Maritzburg United who beat Moroka Swallows 3-1.
Compatriot Awal Mohammed played the entire 90 minutes.
Joetex Frimpong watched from the bench as FC Servette shocked his FC Zurich side 2-0.
Former Hearts of Oak midfielder Uriah Asante scored the opener for Etoile du Sahel who beat Hammam-Sousse 5-1.
Emmanuel Clottey scored his debut goal for Esperance de Tunis as they hammered Olympique du Kef 3-0.
Dynamo Kiev demolished Arsenal Kiev 4-0. Both Dominic Adiyiah and Abeiku Quansah were introduced the second half.
Asamoah Gyan increased his league tally to 17 after bagging a brace for Al Ain in their 5-2 win over FC Dubai.