Ghanaian giants Hearts and Asante Kotoko have been invited for a four-team tournament later this month.
The tournament being put together by Crystal Limited, a non-governmental organization, is also seeking to invite Nigeria pair Enugu Rangers and Eyimba FC.
Each club will be paid an appearance fee of US$ 25,000.
Crystal Limited wants to use the mini-tourney to raise awareness on cancer and kidney diseases.
All matches will be played at the Baba Yara Stadium in Kumasi.
The mid-season tournament will prepare Kotoko for their CAF Champions League first round qualifier against BYC of Liberia.
Hearts of Oak are preparing for the resumption of the Ghana Premier League next month.