A crucial relegation six-pointer kicks things off on Matchday 24, as 16th-placed Mainz host fellow strugglers Wolfsburg on Friday night (kick-off 20:30 CET/19:30 GMT).
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The home team will be confident coming into this one after recording a surprise 2-0 victory away at Hertha Berlin last week, ending a run of four consecutive defeats in all competitions. Currently occupying the relegation play-off spot, Mainz could leapfrog their visitors with a win in this game, and will be bolstered by the return of key defender Abdou Diallo from suspension. Colin Quaison's brace against Hertha means he should keep his place in attacking midfield, with Yoshinori Muto, Emil Berggreen and Anthony Ujah all vying to start up front.
There will be a new face on the touchline for Wolfsburg following Martin Schmidt's surprise resignation on Monday in the wake of the Matchday 23 defeat against Bayern Munich. The Wolves swiftly appointed Bruno Labbadia in his stead, and the 52-year-old is well versed in relegation battles, having managed Hamburg and Stuttgart in recent years. Maximilian Arnold is suspended for this one, so Riechedly Bazoer could start in central midfield, while several first-team regulars including John Brooks, Jakub Blaszczykowski and Ignacio Camacho all remain sidelined through injury.