Medeama will fly out to Congo on Tuesday ahead of Sundayâ€™s CAF Confederation Cup first leg tie against AC Leopards.
A team of 18 players, five technical officials and five management members will leave Ghana for the decisive final qualifying round game.
The Mauve and Yellows are on the brink of history and must negotiate their tie against the Congolese side to make the group phase.
However, they face a plucky Congolese side which won the CAF Confederation Cup in 2012.
AC Leopards were relegated from the Champions League by Sudanese powerhouse Al Hilal.
Medeama can chalk an amazing feat if they progress to the group phase of Africaâ€™s elite inter-club competition.
They have managed successes over Panthers FC, Maghreb de Fes and Zesco United and are confronted with the final hurdle against the former champions.